THE NATURALIST
Fear and Loathing and Cottonmouths
What's a little venom among friends
By Todd Pusser
With the notable exceptions of politicians and the Duke’s men’s basketball team, few living things are viewed with as much contempt and revulsion as snakes. Ever since the serpent tempted Eve in the Garden of Eden, snakes have received bad press. Their credentials for despicability are easy to understand — some can kill a person with a single bite.
Depending on which taxonomist you ask, there are roughly 4,000 species of snakes spread across the globe. Of those, approximately 600 are considered venomous. Breaking that statistic down even further, only about 300 species of snakes possess enough toxicity in their venom to kill a human.
That small percentage (7.5 percent) has instilled an immense fear of snakes in humans across cultures and all walks of life. Some scientists even suggest that the fear is ingrained in our very DNA — a holdover from a time when our distant ancestors walked the landscape without the benefit of antivenom and apps that can identify snakes with a single click of a smartphone. Ophidiophobia, as the fear is known, affects countless people and can cause some to react in very irrational ways.
Peruse news archives over the past decade and you will find many shining examples. One 2021 NBC news headline reads, “Maryland home burns down during owner’s ill-fated snake fight.” Apparently, a man intentionally started a fire in his basement in order to clear a “snake infestation” from under his house by smoking them out. What could go wrong?
Another from Florida reads, “Molino man accidentally shoots himself while trying to kill snake.” A man — yes, a Florida man — encountered a snake in his backyard, went back into his house, loaded a .357 revolver with buckshot, then went back outside and promptly shot himself in the leg when he tripped and fell on the snake.
My personal favorite is a 2017 headline out of Conway, South Carolina, that reads, “Man shoots mother-in-law while trying to kill snake.” I know what you’re thinking — likely story. I was thinking the same thing, but according to WBTW 13 News, the man’s mother-in-law was leaving his house when she encountered a snake near the bottom step of the porch. The report explains the son-in-law was laying “on the ground under the steps and told everyone not to move while he tried to shoot the animal. When he fired, the victim yelled out in pain after the round went through the steps and into her leg.” AI can’t even make this stuff up. Fortunately for the mother-in-law, the wound was not life-threatening. Apparently both the snake and the man survived.
No other snake in the Southeast is associated with more legends and myths than the cottonmouth. Frequenting numerous Mom and Pop tackle shops in my youth, as well as spending most weekends casting a line throughout the Sandhills, I heard many cottonmouth tales. Fisherman swore up and down that cottonmouths were super aggressive and would chase you at every opportunity. Others warned of waterskiers falling into cottonmouth nests and dying on the spot.
As I aged, I realized that these stories simply were not true. Four species of harmless, non-venomous water snakes are found throughout North Carolina. All are large and can be quite common along creeks, lakes and ponds. To the untrained eye, they look a lot like cottonmouths. In the spring, large females are frequently accompanied by amorous, smaller males. These mating assemblages frequently take place out in the open along shorelines, or on tree branches overhanging rivers and lakes, in plain sight of fishermen or swimmers, and are likely the origin of the cottonmouth nest myth.
As far as cottonmouths chasing you, after encountering hundreds in my outdoor adventures, not one has shown any aggression toward me. Many gape their mouths wide open when disturbed, revealing the white interior, which gives them their name. And if provoked, cottonmouths will readily strike in self-defense. In fact, most bites from cottonmouths happen when people are in the process of trying to kill them or actively disturb them. Case in point — an ABC news headline out of Tampa in 2015 reads, “Man bitten when he tries to kiss poisonous snake.” According to the account, an 18-year-old man had captured a cottonmouth in his girlfriend’s yard and kept the snake for a few days in a pillowcase. In an effort to impress his girlfriend, the young fellow would occasionally take the cottonmouth out of the pillowcase and kiss it on the lips. Predictably, the snake decided to end the relationship and bit the man on his face, sending him to the hospital in critical condition. He survived the ordeal, but it just goes to show that Charles Darwin’s Theory of Natural Selection is still functioning well into the 21st century.
Cottonmouth venom is loaded with proteins and enzymes that break down the tissue of their prey. A bite from one is very painful and has, on occasion, caused fatalities in humans. Most readers, I assume, would not mind ridding the world of cottonmouths. “What good are they?” is a question I have frequently been asked over the years with regard to all manner of venomous snakes. Consider these facts: An amino acid, first isolated from cottonmouth venom in the 1950s, has been found to readily kill cancer cells; likewise, research into a protein called contortrostatin, found in the venom of copperheads, the cottonmouth’s closely related (and equally maligned) cousin, has shown significant potential for inhibiting the growth and spread of breast cancer. In a nutshell, ridding the world of venomous snakes could eliminate a potential cure for cancer.
My best advice for someone who encounters a snake, be it venomous or otherwise, is to just leave it alone. Walk away. It’s a safe bet on the current prediction markets that you will never see the snake again. Why risk ending up as a funny news headline trying to kill one?












